
MRS 2578
CAS No. 711019-86-2
MRS 2578 ( MRS-2578 | MRS2578 | MRS 2578 )
产品货号. M19028 CAS No. 711019-86-2
MRS2578 是一种有效的 P2Y6 受体拮抗剂,IC50 为 37 nM,对 P2Y1、P2Y2、P2Y4 和 P2Y11 受体显示出微弱的抑制作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥308 | 有现货 |
![]() ![]() |
10MG | ¥389 | 有现货 |
![]() ![]() |
25MG | ¥851 | 有现货 |
![]() ![]() |
50MG | ¥1442 | 有现货 |
![]() ![]() |
100MG | ¥2325 | 有现货 |
![]() ![]() |
200MG | ¥3499 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称MRS 2578
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述MRS2578 是一种有效的 P2Y6 受体拮抗剂,IC50 为 37 nM,对 P2Y1、P2Y2、P2Y4 和 P2Y11 受体显示出微弱的抑制作用。
-
产品描述MRS-2578 is a selective antagonist of P2Y6 nucleotide receptors (IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively). Activation of P2Y6 receptor amplifies mucosal adenosine triphosphate release underlying bladder overactivity in patients with benign prostatic hyperplasia. Therefore, selective P2Y6 receptor blockade as a novel therapeutic strategy is potentially useful to control persistent storage symptoms in obstructed patients.
-
体外实验MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFα-induced apoptosis in 1321N1 astrocytoma cells. ?MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells.
-
体内实验MRS2578 (3 mg/kg; i.p.; for 3 days) significantly suppresses pressure overload-induced collagen deposition without affecting cardiomyocyte hypertrophy after transverse aortic constriction (TAC). Animal Model:6-week-old male C57BL/6J mice Dosage:3 mg/kg Administration:Intraperitoneal injection; daily for 3 days after TAC Result:Significantly suppressed pressure overload-induced collagen deposition.
-
同义词MRS-2578 | MRS2578 | MRS 2578
-
通路Others
-
靶点Other Targets
-
受体P2Y6
-
研究领域Cardiovascular Disease
-
适应症——
化学信息
-
CAS Number711019-86-2
-
分子量472.67
-
分子式C20H20N6S4
-
纯度>98% (HPLC)
-
溶解度DMSO : ≥ 80 mg/mL; 169.25 mM
-
SMILESS=C=NC1=CC=CC(NC(=S)NCCCCNC(=S)NC2=CC(=CC=C2)N=C=S)=C1
-
化学全称1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Mamedova LK, et al. Biochem Pharmacol, 2004, 67(9), 1763-1770.
产品手册




关联产品
-
Tiomolibdate diammon...
Tiomolibdate diammium 是一种超氧化物歧化酶 1 (SOD1) 抑制剂,具有抗血管生成和抗肿瘤活性。
-
Peonidin-3-O-arabino...
Peonidin-3-O-arabinoside chloride has antioxidant activity.
-
JBSNF-000088
JBSNF-000088 是一种烟酰胺 N-甲基转移酶 (NNMT) 抑制剂。它用于治疗代谢紊乱。